Outcomes were change from baseline resting metabolic rate adjusted for weight change ('RMR residual') and core temperature (primary) plasma triiodothyronine (T3) and tumor necrosis factor-α (secondary) and exploratory physiological and psychological measures.īody mass index averaged 25.1 (range: 21.9-28.0 kg/m(2)). To determine CR's feasibility, safety, and effects on predictors of longevity, disease risk factors, and quality of life in nonobese humans aged 21-51 years, 218 persons were randomized to a 2-year intervention designed to achieve 25% CR or to AL diet.

The implications for humans can be clarified by randomized controlled trials of CR. Eric Ravussin, Catherine Champagne, Alok Gupta, Corby Martin, Leanne Redman, Steven Smith, Donald Williamson, Corby Martin, Michelle Begnaud, Barbara Cerniauskas, Allison Davis, Jeanne Gabrielle, Heather Walden, Natalie Currier, Mandy Shipp, Sarah Masters, Melody McNicoll, Shelly Prince, Courtney Brock, Renee Puyau, Conrad Earnest, Jennifer Rood, Tiffany Stewart, Lillian Levitan, Crystal Traylor, Susan Thomas, Valerie Toups, Karen Jones, Stephanie Tatum, Celeste Waguespack, Kimberly Crotwell, Lisa Dalfrey, Amy Braymer, Rhonda Hilliard, Onolee Thomas, Jennifer Arceneaux, Stacie LaPrarie, Allison Strate, Jana Ihrig, Susan Mancuso, Christy Beard, Alicia Hymel, Desti Shepard, John Correa, Denise Jarreau, Brenda Dahmer, Grace Bella, Elizabeth Soroe, Bridget Conner, Paige McCown, Stephanie Anaya, Melissa Lupo, Susan B Roberts, Sai Krupa Das, Simin Meydani, Roger Fielding, Isaac Greenberg, Anastassios Pittas, Edward Saltzman, Tammy Scott, Cheryl Gilhooly, Kimberly Gerber, Isaac Greenberg, Marjory Kaplan, Christy Karabetian, Russell Kennedy, Lisa Robinson, Verona Bembridge, Maria Berlis, Scarlett Buer, Robert Carabello, Cherie Campbell, Lauren Collins, Marybeth Doherty, Alicia Freed, Chervonte Hernandez, Gyna Jean-Baptiste, Mary Krasinski, Marie Lim-Lucas, Ekaterina Maslova, Barbara Maxwell, Jean McShea, Ann Muchowski, Margaret Mulkerrin, Kerry Murphy, Carol Nelsen, Megan O'Neill, Helen Rasmussen, Brenda Roche, Eneida Roman, Gregory Sproull, Marie St Victor, Susan Storer, Katherine Strissel, Stephanie Valliere, Margaret Vilme, Justin Wheeler, Jill Wiley, Fania Yangarber, John O Holloszy, Luigi Fontana, Sam Klein, Charles Lambert, B Selma Mohammed, Susan Racette, Dennis Villareal, Rick Stein, Karen Cotton, Margaret Hof, Cherie Massmann, Kathleen Obert, Marni Pearlman, Tina M Reising, Laura Weber, Mary Uhrich, Morgan Schram, Mel Meyer, Chelsea Carlen, Lisa Kee, Barbara Larson, Mary McFerson, Rebecca Sabatino, Bridgett Toennies, James Rochon, Connie W Bales, Carl F Pieper, William Kraus, Katherine M Galan, Richard Adrian, Eleanor Law Allen, William Blasko, Manjushri Bhapkar, Nikka Brown, Maria Butts, Elaina K Cossin, Jennifer Curry, Jamie Daniel, Kathleen S Diemer, Lee Greiner, Darryl Johnson, Cassandra Jones, Lauren Lindblad, Luanne McAdams, Marty Mansfield, Senthil Murugesan, Lucy Piner, Christopher Plummer, Mike Revoir, Pamela Smith, Monica Spaulding, James Topping, William W Wong, Lucinda L Clarke, Chun W Liu, J Kennard Fraley, Ann V Schwartz, John Shepherd, Lisa Palermo, Susan Ewing, Michaela Rahorst, Caroline Navy, Michael Lewis, Russell P Tracy, Rebekah Boyle, Elaine Cornell, Patrick Daunais, Dean Draayer, Melissa Floersch, Nicole Gagne, Florence Keating, Angela Patnoad, Marcia Schmidt, Marcia Gavin, Frida Wiener, Ashley Hughes, Laura Benken, Amy Otto, Jeffrey Halter, David M Buchner, Patricia Elmer, Mark Espeland, Steven B Heymsfield, Xavier Pi-Sunyer, Thomas Prohaska, Sue Shapses, John Speakman, Richard Weindruch, Evan C Hadley, Judy Hannah, Sergei Romashkan, Mary EvansĬaloric restriction (CR), energy intake reduced below ad libitum (AL) intake, increases life span in many species.

Jana shepard edward jones